Metformin

The percentage on each node is the confidence level that a particular benefit or side effect is actually real — higher means more high-quality studies back it up. Once confidence crosses ~80%, the effect is considered Pacified: generally accepted as true by the scientific community.

Position reflects confidence: nodes closer to the center have stronger evidence; nodes near the edge are still speculative. As more studies are published, nodes migrate inward — or disappear entirely if the evidence collapses.

Metformin has been studied for over 60 years, so its sphere looks very different from a newer drug's: most nodes sit tightly packed in the Core — a dense cluster of effects that science has thoroughly verified. The nodes near the edge represent genuinely open questions, like whether metformin slows aging itself, which is only now being tested in formal human trials.