GLP-1

Glucagon-Like Peptide-1 Receptor Agonists

GLP-1 receptor agonists (semaglutide, tirzepatide, liraglutide) mimic a gut hormone that regulates blood sugar and appetite. Originally developed for type 2 diabetes, they have since demonstrated broad effects across cardiovascular, neurological, and metabolic systems.

Last updated
2026-04-21

How to read this sphere

The percentage on each node is the confidence level that a particular benefit or side effect is actually real — higher means more high-quality studies back it up. Once confidence crosses ~80%, the effect is considered Pacified: generally accepted as true by the scientific community.

Position reflects confidence: nodes closer to the center have stronger evidence; nodes near the edge are still speculative. As more studies are published, nodes migrate inward — or disappear entirely if the evidence collapses.

GLP-1 is a relatively new drug, so its sphere is spread out with many nodes still in the outer layers — a lot of active research is still running. Older, well-studied drugs tend to have a denser, more compact core with little left in the outer rings.

13
Benefits
13
Malefices
31
Sources
67%
Avg. Confidence
BENEFITSMALEFICESCore80–100%Inner Mantle60–80%Outer Mantle40–60%Crust10–40%PMDD Symptom Red… (C.L. 20%)"The GLP-1 Glow" (C.L. 20%)Neuroprotection … (C.L. 48%)PCOS Symptom Imp… (C.L. 55%)Addiction & Impu… (C.L. 62%)Inflammation Red… (C.L. 72%)Heart Failure Im… (C.L. 83%)Liver Health Imp… (C.L. 85%)Sleep Apnea Redu… (C.L. 88%)Kidney Disease P… (C.L. 90%)Cardiovascular P… (C.L. 97%)Weight Loss (C.L. 98%)Glycemic Control (C.L. 99%)Suicidal Ideatio… (C.L. 20%)Anhedonia (C.L. 25%)"Ozempic Babies" (C.L. 35%)"Ozempic Burps" (C.L. 40%)Hair Loss (C.L. 45%)Gastroparesis (C.L. 58%)Muscle Mass Loss (C.L. 72%)"Ozempic Face/Bo… (C.L. 75%)Diabetic Retinop… (C.L. 80%)Thyroid C-cell T… (C.L. 85%)Gallstones (C.L. 88%)Pancreatitis Risk (C.L. 90%)GI Distress (C.L. 99%)

All Sources

Phase III RCT11 sources
Meta-Analysis6 sources
Observational Study9 sources
Regulatory3 sources
Anecdotal / Forum2 sources

Last updated: 2026-04-21 · Data compiled from PubMed, ClinicalTrials.gov, FDA, and EMA databases.