Leqembi & Kisunla

The percentage on each node is the confidence level that a particular benefit or side effect is actually real — higher means more high-quality studies back it up. Once confidence crosses ~80%, the effect is considered Pacified: generally accepted as true by the scientific community.

Position reflects confidence: nodes closer to the center have stronger evidence; nodes near the edge are still speculative. As more studies are published, nodes migrate inward — or disappear entirely if the evidence collapses.

These are new drugs — both approved 2023–2024. The pivotal trials ran for only 18 months, so this sphere reflects the earliest chapter of what will be a decades-long evidence story. The ARIA safety nodes are well-established; the cognitive benefit nodes will likely shift inward as longer-term data emerge. Watch this sphere change.